CTSI Special Populations: 5Ts Framework

5Ts Graphic

 

Additional publicaton in progress

In collaboration with Barrett Bowling, MD Jennifer Thomas, MPH, and other cross-CTSA authors, we submitted a 5Ts research letter highlighting the CCSs in older adults and other special populations.

The research letter titled, 'Recommendations for using the 5Ts Framework to support inclusion across the lifespan' was submitted to the Journal of American Geriatrics in January 2023 and currently under review. 

Overview

The Integrating Special Populations Core assisted Barrett Bowling, MD, in developing the 5Ts Research Framework. Although the framework was designed to facilitate the inclusion of older adults in clinical research, the ISP Core has recognized and will promote its relevance as a tool to facilitate inclusion of multiple special populations. 

The website/prototype tool (beta v.) to facilitate inclusion of older adults in clinical research should be finalized by early 2023.

Expanding the 5Ts to other Special Populations

We have expanded the 5Ts recommendations to African-American and LatinX populations across the lifespan and worked with CERI to conduct community consult studios (CCSs) with participants from these demographic groups and with research coordinators who have successfully recruited and retained these populations for clinical research studies.

Using the 5Ts, we generated recommendations on how to increase enrollment of African-Americans and LatinX participants in clinical research from the feedback we received from these CCSs. Once the 5Ts website is developed for older adults, we plan to be ready to expand it to assist investigators to include other special populations in clinical research.