Below is a selection of African American firsts at Duke Medicine, arranged alphabetically.
- Onye Akwari – First black professor of surgery at Duke’s School of Medicine, 1978
- Brenda Armstrong – First African American to serve as a full professor in pediatrics in the School of Medicine and the first to be board certified in pediatric cardiology in the U.S.
- Jacqueline S. Barnett- First African American director of the Physician Assistant Program
- Haywood Brown – First African American chair of the Department of Obstetrics and Gynecology at the Medical Center, 2002
- James Carter – First African American professor of psychiatry at Duke’s School of Medicine, 1971
- Charles Curry – First African American fellow in Adult Cardiology at Duke’s School of Medicine, 1982
- Sayde Curry – First African American woman postgraduate trainee (Gastroenterology), 1969
- Kafui Dzirasa – First Black neurobiology Ph.D. student, 2007
- Donna Allen Harris – First African American School of Nursing student, 1967
- Prentiss L. Harrison – Nation’s first African American Physician Assistant; graduate of the Duke program, 1968
- Eddie L. Hoover – First African American house officer, 1969
- Danny O. Jacobs – First African American chair of Surgery at the Medical Center, 2003
- Jacquelyne J. Jackson- First tenured female black faculty member in Duke's School of Medicine
- Charles Johnson – First African American fellow in Endocrinology at Duke’s School of Medicine, 1967, and first African American faculty member, 1970
- W. Delano Meriwether – First African American student admitted to Duke's School of Medicine, 1963
- Donald T. Moore – First Black physician to hold clinical appointment on the Duke hospital staff, 1966
- Jean Spaulding – First African American woman to graduate from Duke’s School of Medicine, 1972
- Joanne A. P. Wilson – First African American woman, and the first woman, to serve as a full professor in the Duke Department of Internal Medicine, 1986